Hydrochloric Acid → HCID 66701083, compound

HRID 1253684Notes

Reaction equation

HRID 1253684 reaction equation
[ClH:1].[C:2]([N:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH2:29][CH2:28][C:15]3([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1)([CH3:5])([CH3:4])[CH3:3]>CO>[ClH:1].[ClH:1].[ClH:1].[C:2]([N:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH2:29][CH2:28][C:15]3([CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1)([CH3:5])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66701031HCID 66701031, compound

Product 1

HCID 66701083HCID 66701083, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen chloride in methanol (1.25 mol/l, 5.3 ml) was added to tert-butyl 9-(4-tert-butylpiperazin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate (0.26 g, 0.661 mmol) and the mixture was refluxed for 1 h. The solvent was removed in vacuo, the residue was taken up in ethanol (10 ml) and the mixture was stirred for 15 min. Diethyl ether (50 ml) was added and the mixture was then stirred at room temperature. The precipitate was filtered out with suction, washed with diethyl ether and dried in vacuo. Yield: 0.23 g (86%)

Workup

  1. temperaturethe mixture was refluxed for 1 h
  2. customThe solvent was removed in vacuo
  3. additionDiethyl ether (50 ml) was added
  4. stirringthe mixture was then stirred at room temperature
  5. filtrationThe precipitate was filtered out with suction
  6. washwashed with diethyl ether
  7. customdried in vacuo

Sources & evidence

ORD record
ord-948f500a7a614ac7beae7cf146e3770c
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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