Trifluoroacetic acid → HCID 59505553, compound

HRID 1253699Notes

Reaction equation

HRID 1253699 reaction equation
C(O)(C(F)(F)F)=O.[F:8][C:9]([F:34])([F:33])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:32][CH2:31][C:19]3([CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[CH2:18][CH2:17]2)[CH:13]=[CH:12][N:11]=1>C(Cl)Cl>[F:34][C:9]([F:8])([F:33])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:17][CH2:18][C:19]3([CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:31][CH2:32]2)[CH:13]=[CH:12][N:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66701130HCID 66701130, compound

Product 1

HCID 59505553HCID 59505553, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

TFA (1.5 ml) is added to a solution of tert-butyl 8-(2-(trifluoromethyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.64 mmol, 1.0 eq.) in methylene chloride (5 ml) at 0° C. and the reaction mixture is stirred at 25° C. for 1 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-26).

Workup

  1. customthe solvent was removed in vacuo in order

Sources & evidence

ORD record
ord-0c72cbf7499441c79141e1a57102721c
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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