Trifluoroacetic acid → HCID 59505696, compound

HRID 1253701Notes

Reaction equation

C(O)(C(F)(F)F)=O.[F:8][C:9]([F:38])([F:37])[C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:19]=1[N:18]=[CH:17][CH:16]=[C:15]2[N:20]1[CH2:36][CH2:35][C:23]2([CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]2)[CH2:22][CH2:21]1>C(Cl)Cl>[CH2:27]1[C:23]2([CH2:35][CH2:36][N:20]([C:15]3[C:14]4[C:19](=[C:10]([C:9]([F:37])([F:38])[F:8])[CH:11]=[CH:12][CH:13]=4)[N:18]=[CH:17][CH:16]=3)[CH2:21][CH2:22]2)[CH2:24][CH2:25][NH:26]1

Participants

Conditions

Temperature: 25 °C

Procedure

TFA (1 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(8-(trifluoromethyl)quinolin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.69 mmol, 1.0 eq.) in methylene chloride (4 ml) and the reaction mixture was stirred at 25° C. for 2 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-27).

Workup

customthe solvent was removed in vacuo in order

Sources & evidence

ORD record: ord-4ca7cc0443ea457a9ba8dbbf57ae2ac4
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08455475B2

Reaction notes

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