Trifluoroacetic acid → 6-(2,8-Diazaspiro[4.5]decan-8-yl)isoquinoline trifluoroacetate

HRID 1253704Notes

Reaction equation

HRID 1253704 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[CH:8]1[C:17]2[C:12](=[CH:13][C:14]([N:18]3[CH2:34][CH2:33][C:21]4([CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=2)[CH:11]=[CH:10][N:9]=1>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[CH2:25]1[C:21]2([CH2:20][CH2:19][N:18]([C:14]3[CH:13]=[C:12]4[C:17](=[CH:16][CH:15]=3)[CH:8]=[N:9][CH:10]=[CH:11]4)[CH2:34][CH2:33]2)[CH2:22][CH2:23][NH:24]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66700964tert-Butyl 8-(isoquinolin-6-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Product 1

HCID 667008626-(2,8-Diazaspiro[4.5]decan-8-yl)isoquinoline trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (2 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(isoquinolin-6-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.544 mmol, 1.0 eq.) in methylene chloride (10 ml) and the reaction mixture was stirred at room temperature for 1 h. When the reaction was complete, the solvent was removed on a rotary evaporator. The crude product was employed directly in the next step.

Workup

  1. customthe solvent was removed on a rotary evaporator

Sources & evidence

ORD record
ord-752605ce4fd6466dace6c3c4d4b3e79b
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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