Trifluoroacetic acid → HCID 59505729, compound

HRID 1253727Notes

Reaction equation

C(O)(C(F)(F)F)=O.[F:8][C:9]([F:34])([F:33])[C:10]1[CH:11]=[N:12][C:13]([N:16]2[CH2:32][CH2:31][C:19]3([CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[CH2:18][CH2:17]2)=[N:14][CH:15]=1>C(Cl)Cl>[F:33][C:9]([F:8])([F:34])[C:10]1[CH:11]=[N:12][C:13]([N:16]2[CH2:32][CH2:31][C:19]3([CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:18][CH2:17]2)=[N:14][CH:15]=1

Participants

Conditions

Temperature: 25 °C

Procedure

TFA (1.5 ml) was added to a solution of tert-butyl 8-(5-(trifluoromethyl)pyrimidin-2-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (300 mg, 0.78 mmol, 1.0 eq.) in methylene chloride (6 ml) at 0° C. and the reaction mixture was stirred at 25° C. for 1 h. After completion of the reaction, the solvent was evaporated under reduced pressure to give the desired product as a yellow sticky solid which was directly used in the next step.

Workup

customAfter completion of the reaction
customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-ee625a2c10b741b0985bacd43a61af0b
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08455475B2

Reaction notes

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