Trifluoroacetic acid → HCID 59505716, compound

HRID 1253741Notes

Reaction equation

HRID 1253741 reaction equation
C(O)(C(F)(F)F)=O.[N:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][C:17]3([CH2:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>C(Cl)Cl>[N:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:19][CH2:18][C:17]3([CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:16][CH2:15]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66701180HCID 66701180, compound

Product 1

HCID 59505716HCID 59505716, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.0 ml) was added to a solution of tert-butyl 3-(pyridin-4-yl)-3,9-diazaspiro[5.6]dodecane-9-carboxylate (250 mg, 0.724 mmol) in methylene chloride (3 ml) at 0° C. and the resulting reaction mixture was stirred at RT for 2 h. The solvent was evaporated under reduced pressure and the residue was azeotroped with toluene to give the desired product which was used in the next step without further purification.

Workup

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was azeotroped with toluene

Sources & evidence

ORD record
ord-9d72ff516f914c888a5c5b3673e03198
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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