Trifluoroacetic acid → HCID 59505478, compound

HRID 1253744Notes

Reaction equation

HRID 1253744 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:32][CH2:31][C:19]3([CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[CH2:18][CH2:17]2)=[CH:12][CH:11]=1>C(Cl)Cl>[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:17][CH2:18][C:19]3([CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:31][CH2:32]2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66701168HCID 66701168, compound

Product 1

HCID 59505478HCID 59505478, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.2 ml) was added to a solution of tert-butyl 8-(4-methoxyphenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (200 mg, 0.57 mmol, 1.0 eq.) in methylene chloride (5 ml) at 0° C. and the reaction mixture was stirred at RT for 1 h. After completion of the reaction, the solvent was evaporated under reduced pressure to give the desired product as a yellow sticky solid which was used in the next step without further purification.

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-4bc2a05868b743d394280cd18101b785
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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