反应详情

TFA (1 ml) was added to a stirred solution of tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (840 mg, 2.5 mmol) in MC (4 ml) and the mixture was stirred at RT for 12 h. The reaction mixture was then concentrated under reduced pressure and azeotroped with MC (2×10 ml). The crude product was dried and used for the next step without further purification.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. customazeotroped with MC (2×10 ml)
3. dry with materialThe crude product was dried
4. customused for the next step without further purification