Nicotinic Acid → N-[5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide

HRID 1253781Notes

Reaction equation

HRID 1253781 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([NH2:18])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:19](O)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>>[CH:1]1([C:6]2[CH:7]=[C:8]([NH:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=3)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 712941725-Cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 71294278N-[5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamideYield 50.6%

Procedure

This compound was prepared following the same procedure as described for Example 3 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 1c) (100 mg, 0.38 mmol) and nicotinic acid (40.6 mg, 0.33 mmol) as starting materials. The title compound (61 mg, 43.3%) was isolated as off white solid; MS (ESI): 366 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-6b453ff2fd0b4791b7966fdcff557f04
Source dataset
uspto-grants-2013_06
Patent number
US08455501B2

Reaction notes

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