5-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine → HCID 178426984, compound

HRID 1253787Notes

Reaction equation

HRID 1253787 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([NH2:19])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][C:21]1[CH:22]=[C:23]([C:26](O)=[O:27])[NH:24][N:25]=1>>[CH:1]1([C:7]2[CH:8]=[C:9]([NH:19][C:26]([C:23]3[NH:24][N:25]=[C:21]([CH3:20])[CH:22]=3)=[O:27])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 712941485-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamineHCID 178427254HCID 178427254, compound

Product 1

HCID 178426984HCID 178426984, compoundYield 53.1%

Procedure

This compound was prepared following the same procedure as described for Example 3 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 8b) (100 mg, 0.36 mmol) and 5-methyl-2H-pyrazole-3-carboxylic acid (40.6 mg, 0.33 mmol) as starting materials. The title compound (67 mg, 48.2%) was isolated as off white solid; MS (ESI): 383 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c23e62db8f3c44d395891d3eb44a4791
Source dataset
uspto-grants-2013_06
Patent number
US08455501B2

Reaction notes

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