5-methyl-1,3-oxazole-4-carboxylic Acid → 5-Methyl-oxazole-4-carboxylic acid [5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide

HRID 1253788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1253788
[CH:1]1([C:7]2[CH:8]=[C:9]([NH2:19])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][C:21]1[O:25][CH:24]=[N:23][C:22]=1[C:26](O)=[O:27]>>[CH:1]1([C:7]2[CH:8]=[C:9]([NH:19][C:26]([C:22]3[N:23]=[CH:24][O:25][C:21]=3[CH3:20])=[O:27])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

3

Edukt 2

HCID 113554845-methyl-1,3-oxazole-4-carboxylic AcidHCID 71294148HCID 71294148, Verbindung

Produkt 1

HCID 715097375-Methyl-oxazole-4-carboxylic acid [5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amideAusbeute 48,5 %

Versuchsvorschrift

This compound was prepared following the same procedure as described for Example 3 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 8b) (100 mg, 0.36 mmol) and 5-methyl-4-oxazolecarboxylic acid (71 mg, 0.55 mmol) as starting materials. The title compound (67 mg, 47.2%) was isolated as off white solid; MS (ESI): 384 [M+H]+.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-45276bb08714433281f80ce7793afd9a
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455501B2

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