5-methyl-1,3-oxazole-4-carboxylic Acid → 5-Methyl-oxazole-4-carboxylic acid [5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide

Participants

Reaction Steps

This compound was prepared following the same procedure as described for Example 3 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 8b) (100 mg, 0.36 mmol) and 5-methyl-4-oxazolecarboxylic acid (71 mg, 0.55 mmol) as starting materials. The title compound (67 mg, 47.2%) was isolated as off white solid; MS (ESI): 384 [M+H]+.

Provenance & Evidence