反应详情

To a solution of 2,3-dihydro-1H-inden-1-carboxylic acid (0.50 g) in tetrahydrofuran (5.0 mL), lithium aluminum hydride (0.18 g) was added under ice-cooling and the resultant reaction mixture was stirred at room temperature for 30 minutes. To the reaction mixture, water was added under ice-cooling and the resultant reaction mixture was extracted with ethyl acetate. The organic phase was washed with a saturated saline and was dried over anhydrous sodium sulfate. From the organic phase, the solvent was distilled off under reduced pressure and the resultant residue was purified by silica gel column chromatography (eluate: n-hexane:ethyl acetate=85:15 to 75:25) to obtain the subject compound (445 mg) as a colorless oil.

1. temperaturecooling
2. customthe resultant reaction mixture
3. temperaturecooling
4. customthe resultant reaction mixture
5. extractionwas extracted with ethyl acetate
6. washThe organic phase was washed with a saturated saline
7. dry with materialwas dried over anhydrous sodium sulfate
8. distillationFrom the organic phase, the solvent was distilled off under reduced pressure
9. customthe resultant residue was purified by silica gel column chromatography (eluate: n-hexane:ethyl acetate=85:15 to 75:25)