Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Reactant | HCID 49719425 | HCID 49719425 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 67283800 | HCID 67283800 | 55% |
Reaction Steps
A suspension of 1-tosyl-4-(2,2,2-trifluoroethyl)piperazine (700 mg, 2.2 mmol) in a 30% HBr/acetic acid solution was stirred at 90° C. for 90 minutes. Toluene was added to the suspension. An orange solid was filtered off and washed with diethyl ether to afford the desired compound (400 mg, 55% yield) as a bis HBr salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08455507B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-5f611412e4834a08b12e9c9c8019c399 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
