Hydrogen Bromide → HCID 67283800, compound

HRID 1253815Notes

Reaction equation

HRID 1253815 reaction equation
S([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:13][CH2:12]1)(C1C=CC(C)=CC=1)(=O)=O.[BrH:22].C(O)(=O)C.Br>C1(C)C=CC=CC=1>[BrH:22].[BrH:22].[F:21][C:18]([F:19])([F:20])[CH2:17][N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 49719425HCID 49719425, compound

Product 1

HCID 67283800HCID 67283800, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of 1-tosyl-4-(2,2,2-trifluoroethyl)piperazine (700 mg, 2.2 mmol) in a 30% HBr/acetic acid solution was stirred at 90° C. for 90 minutes. Toluene was added to the suspension. An orange solid was filtered off and washed with diethyl ether to afford the desired compound (400 mg, 55% yield) as a bis HBr salt.

Workup

  1. filtrationAn orange solid was filtered off
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-5f611412e4834a08b12e9c9c8019c399
Source dataset
uspto-grants-2013_06
Patent number
US08455507B2

Reaction notes

Loading…