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HRID1253856

反应详情

EQUATION

反应方程式

HRID 1253856 的结构方程式

REACTANTS

反应物

3
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：O=C(O)CCl
HCID300

Chloroacetic acid

C2H3ClO2

结构：Nc1ccc2cnccc2c1
HCID588991

6-Aminoisoquinoline

C9H8N2

PRODUCTS

生成物

1
结构：O=C(CCl)Nc1ccc2cnccc2c1
HCID24999501

2-Chloro-N-(isoquinolin-6-yl)acetamide

C11H9ClN2O

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To chloroacetic acid in DMF was added EDC, DMAP and 6-aminoisoquinoline. This mixture was stirred for 4 hours. The reaction was washed with NaHCO3(sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave 2-chloro-N-(isoquinolin-6-yl)acetamide (E1).

WORKUP

后处理

  1. washThe reaction was washed with NaHCO3(sat)
  2. extractionextracted with EtOAc
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated