HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2-Dichloroethane → 2-chloro-N-(isoquinolin-6-yl)acetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2-Dichloroethane | HCID 11 | — |
| Edukt | Chloroacetic Acid | HCID 300 | — |
| Edukt | 6-Aminoisoquinoline | HCID 588991 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-chloro-N-(isoquinolin-6-yl)acetamide | HCID 24999501 | — |
Reaktionsschritte
To chloroacetic acid in DMF was added EDC, DMAP and 6-aminoisoquinoline. This mixture was stirred for 4 hours. The reaction was washed with NaHCO3(sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave 2-chloro-N-(isoquinolin-6-yl)acetamide (E1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08455513B2 |
| Quelldatensatz | uspto-grants-2013_06 |
| ORD ID | ord-912cf728cf3e48bf989c4dbfb9ed1f97 |
| Quellennotiz | uspto-grants-2013_06 |