Ammonia → HCID 10490937, compound

HRID 1253924Notes

Reaction equation

HRID 1253924 reaction equation
[Br:1][C:2]1[C:3]([Cl:13])=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7](OC)=[O:8].[NH3:14]>CO>[Br:1][C:2]1[C:3]([Cl:13])=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([NH2:14])=[O:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 26370240Methyl 5-bromo-4-chloro-2-hydroxybenzoate

Product 1

HCID 10490937HCID 10490937, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

A mixture of methyl 5-bromo-4-chloro-2-hydroxybenzoate (2.655 g, 10.00 mmol) in a solution of ammonia (50.0 ml, 100 mmol) in MeOH was heated at 65° C. for 72 hr. After concentration, the title product was obtained as solid (2.53 g). ESI-MS m/z: 252.1 [M+1]+, Retention time 1.19 min; 1HNMR (CDCl3, 400.342 MHz) δ 7.15 (s, 1H), 7.61 (s, 1H), 12.2 (brs, 1H).

Workup

  1. concentrationAfter concentration

Sources & evidence

ORD record
ord-6f2ba2a43a9c408b81325a679df13d7f
Source dataset
uspto-grants-2013_06
Patent number
US08455522B2

Reaction notes

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