2-Pyridinecarboxaldehyde → Ethyl 3-(4-Ethylphenyl)-[2,2']-bipyridinyl-6-carboxylate

HRID 12540Notes

Reaction equation

HRID 12540 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=O.[CH2:9]([O:11][C:12]([C:14](=[CH:35][CH:36]=[CH:37][C:38]1[CH:43]=[CH:42][C:41]([CH2:44][CH3:45])=[CH:40][CH:39]=1)[N:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:13])[CH3:10]>C(#N)C>[CH2:44]([C:41]1[CH:40]=[CH:39][C:38]([C:37]2[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[N:15][C:14]([C:12]([O:11][CH2:9][CH3:10])=[O:13])=[CH:35][CH:36]=2)=[CH:43][CH:42]=1)[CH3:45]

Participants

4

Reactant 2

HCID 142732-PyridinecarboxaldehydeHCID 866190693-Ethoxycarbonyl-1,1,1-triphenyl-6-(4-ethylphenyl)-2-aza-1lambda5-phosphahexa-1,3,5-triene2×

Product 1

HCID 68409104Ethyl 3-(4-Ethylphenyl)-[2,2']-bipyridinyl-6-carboxylate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following General Procedure K, 2-pyridinecarboxaldehyde (41 mg, 0.38 mmol) and 3-ethoxycarbonyl-1,1,1-triphenyl-6-(4-ethylphenyl)-2-aza-1λ5-phosphahexa-1,3,5-triene (Compound 46, 193 mg, 0.38 mmol) in dry acetonitrile (5 ml) were reacted to produce the title compound as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d60f8401e2e744eba24dc3965d488e26
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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