N-Iodosuccinimide → HCID 178433059, compound

HRID 1254031Notes

Reaction equation

HRID 1254031 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:5][N:6]=1.[I:17]N1C(=O)CCC1=O>>[I:17][C:5]1[N:6]=[C:2]([CH3:1])[NH:3][C:4]=1[C:7]1[CH:8]=[CH:9][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 66986114HCID 66986114, compound

Product 1

HCID 178433059HCID 178433059, compound

Conditions

Temperature
25 °C

Procedure

To the product of Step 2 (750 mg, 3.2 mmol) in 10 mL of CFI3CN was added N-iodosuccinimide (710 mg, 3.2 mmol). The mixture was stirred at 25° C. for 1 h, cooled to −20° C. The precipitate was collected by filtration, washed with cold Et2O and dried to give 4-iodo-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-imidazole. LCMS: [M+1]+=362.9.

Workup

  1. temperaturecooled to −20° C
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with cold Et2O
  4. customdried

Sources & evidence

ORD record
ord-3cfff22171194080b2cec5767bfe7d3e
Source dataset
uspto-grants-2013_06
Patent number
US08455528B2

Reaction notes

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