m-Chloroperbenzoic acid → HCID 67314368, compound

HRID 1254083Notes

Reaction equation

HRID 1254083 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770, compound

Product 1

HCID 67314368HCID 67314368, compoundYield 73.9%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

Sources & evidence

ORD record
ord-c69c06a9357844abb74d7c552645d600
Source dataset
uspto-grants-2013_06
Patent number
US08455535B2

Reaction notes

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