Ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate → Methyl 5-(4-Ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate

HRID 12541Notes

Reaction equation

HRID 12541 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:25]([O:27][CH2:28]C)=[O:26])=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1)[CH3:2]>OS(O)(=O)=O.CO>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:25]([O:27][CH3:28])=[O:26])=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 68407277Ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate2×

Product 1

HCID 59338835Methyl 5-(4-Ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate (Compound 48, 60 mg, 0.15 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2678073f777c403da66620f9ff443181
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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