Methanol → Tert-butyl 3-(4-bromo-2-nitroanilino)-4-hydroxypyrrolidine-1-carboxylate

HRID 125413Notes

Reaction equation

HRID 125413 reaction equation
[Br:1][c:2]1[cH:3][c:4]([N+:26](=[O:27])[O-:28])[c:5]([NH:8][CH:9]2[CH2:10][N:11]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:12][CH:13]2[O:14][C:15](=[O:16])[CH2:17][Cl:18])[cH:6][cH:7]1.[CH3:31][OH:32].[Li+:29].[OH-:30]>>[Br:1][c:2]1[cH:3][c:4]([N+:26](=[O:27])[O-:28])[c:5]([NH:8][CH:9]2[CH2:10][N:11]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:12][CH:13]2[OH:14])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961HydroxideHCID 28486Lithium ionHCID 87361619Tert-butyl 3-(4-bromo-2-nitroanilino)-4-(2-chloroacetyl)oxypyrrolidine-1-carboxylate

Product 1

HCID 67334680Tert-butyl 3-(4-bromo-2-nitroanilino)-4-hydroxypyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-780d55ca2c044821a32f4886fb37366c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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