Hydrochloric Acid → 1-Phenyl-1-(piperidin-3-yl)heptan-1-ol

HRID 1254189노트

반응식

HRID 1254189 반응식
[OH:1][C:2]([CH:15]1[CH2:20][CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl>CC#N>[C:9]1([C:2]([CH:15]2[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]2)([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59382974Tert-butyl 3-(1-hydroxy-1-phenylheptyl)piperidine-1-carboxylate

생성물 1

HCID 593829241-Phenyl-1-(piperidin-3-yl)heptan-1-ol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of tert-Butyl 3-(1-hydroxy-1-phenylheptyl)piperidine-1-carboxylate, obtained as described above, in CH3CN (40 mL) and 2 N HCl (40 mL) was vigorously stirred at rt for 20 h. 60 mL of the reaction mixture was quenched with saturated NaHCO3, extracted three times with EtOAc, and dried over Na2SO4. The crude product (0.2709 g, 80% in two steps) was used without further purification. LC-MS (3 min) tR=1.29 min in 3 min chromatography, m/z 276 (MH+).

후처리

  1. customobtained
  2. custom60 mL of the reaction mixture was quenched with saturated NaHCO3
  3. extractionextracted three times with EtOAc
  4. dry with materialdried over Na2SO4
  5. customThe crude product (0.2709 g, 80% in two steps) was used without further purification

출처 및 근거

ORD 기록
ord-fced1fd826e54a768bb8587ffea0fc39
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455521B2

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