反应详情

A mixture of tert-Butyl 3-(1-hydroxy-1-phenylheptyl)piperidine-1-carboxylate, obtained as described above, in CH3CN (40 mL) and 2 N HCl (40 mL) was vigorously stirred at rt for 20 h. 60 mL of the reaction mixture was quenched with saturated NaHCO3, extracted three times with EtOAc, and dried over Na2SO4. The crude product (0.2709 g, 80% in two steps) was used without further purification. LC-MS (3 min) tR=1.29 min in 3 min chromatography, m/z 276 (MH+).

1. customobtained
2. custom60 mL of the reaction mixture was quenched with saturated NaHCO3
3. extractionextracted three times with EtOAc
4. dry with materialdried over Na2SO4
5. customThe crude product (0.2709 g, 80% in two steps) was used without further purification