Methylamine → HCID 57544804, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2-(tert-butoxycarbonylamino)-4-methoxy-4-methylpentyl methane-sulfonate (1.08 g, 2.99 mmol) in MeOH was added methylamine in methanol (33 wt %, 4.0 mL). The resulting solution was heated in CEM microwave reactor at 120° C. for 5 min. Reaction completion was confirmed by LC-MS. Solvent was removed under vacuum to give a crude (S)-tert-butyl 4-methoxy-4-methyl-1-(methylamino)pentan-2-ylcarbamate, which was used for the next step without purification. MS m/z 261 (M+H+).

Provenance & Evidence