Methylamine → HCID 57544804, compound

HRID 1254365Notes

Reaction equation

HRID 1254365 reaction equation
CS(O[CH2:6][C@@H:7]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:8][C:9]([O:12][CH3:13])([CH3:11])[CH3:10])(=O)=O.[CH3:22][NH2:23]>CO>[CH3:13][O:12][C:9]([CH3:11])([CH3:10])[CH2:8][C@H:7]([NH:14][C:15](=[O:16])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:6][NH:23][CH3:22]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57544571HCID 57544571, compound

Product 1

HCID 57544804HCID 57544804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
120 °C

Procedure

To a solution of (S)-2-(tert-butoxycarbonylamino)-4-methoxy-4-methylpentyl methane-sulfonate (1.08 g, 2.99 mmol) in MeOH was added methylamine in methanol (33 wt %, 4.0 mL). The resulting solution was heated in CEM microwave reactor at 120° C. for 5 min. Reaction completion was confirmed by LC-MS. Solvent was removed under vacuum to give a crude (S)-tert-butyl 4-methoxy-4-methyl-1-(methylamino)pentan-2-ylcarbamate, which was used for the next step without purification. MS m/z 261 (M+H+).

Workup

  1. customReaction completion
  2. customSolvent was removed under vacuum

Sources & evidence

ORD record
ord-cbba4fb4604045e49916d52b407541eb
Source dataset
uspto-grants-2013_06
Patent number
US08455521B2

Reaction notes

Loading…