HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 57544763, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | HCID 1501975 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57544763 | HCID 57544763 | — |
Reaction Steps
To a stirred solution 4-nitrophenyl chloroformate (26.0 mg, 0.13 mmol) in anhydrous CH2Cl2 was added a solution of (S)-tert-butyl 3-aminopiperidine-1-carboxylate (27.0 mg, 0.13 mmol) and pyridine (7 μL) in CH2Cl2 (0.5 mL). The mixture was stirred for 30 min. LC-MS showed complete conversion. This intermediate was used as a solution for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455521B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-47185019806d4bf08c3baf3e7348d390 |
| Source note | uspto-grants-2013_06 |