HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Aminopropylphosphonic acid → (3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Aminopropylphosphonic acid | HCID 97587 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 5-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde | HCID 86619071 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid | HCID 59504176 | — |
Reaktionsschritte
Following General Procedure M, 5-(4-trifluoromethylphenyl)-6-phenyl-pyridine-2-carbaldehyde (Compound 57, 58 mg, 0.18 mmol), (3-amino-propyl)-phosphonic acid (25 mg, 0.18 mmol), Bu4NOH (0.18 ml, 0.18 mmol, 1 M in MeOH) and NaCNBH3 (11 mg, 0.18 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728014B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-6c223868fa6e418e812f48b461d0ad88 |
| Quellennotiz | uspto-grants-2010_06 |