4-Fluoro-3-methoxybenzenesulfonyl chloride → 4-Chloro-3-methoxybenzene-1-sulfonyl chloride

HRID 1254923Notes

Reaction equation

HRID 1254923 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[O:12][CH3:13].[Cl:14]C1C=CC(N)=CC=1OC>>[Cl:14][C:2]1[CH:7]=[CH:6][C:5]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[O:12][CH3:13]

Participants

3

Reactant 2

HCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×HCID 131036924-Chloro-3-methoxyaniline

Product 1

HCID 508760254-Chloro-3-methoxybenzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-chloro-3-methoxy-phenylamine.

Sources & evidence

ORD record
ord-02435f84478d4cc187b6408aaba60737
Source dataset
uspto-grants-2013_06
Patent number
US08455645B2

Reaction notes

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