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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1254923Generated: November 3, 2026

4-Fluoro-3-methoxybenzenesulfonyl chloride → 4-Chloro-3-methoxybenzene-1-sulfonyl chloride

https://huagongshe.com/reaction/1254923

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-methoxybenzenesulfonyl chlorideHCID 2783408—
Reactant4-Chloro-3-methoxyanilineHCID 13103692—
Product4-Chloro-3-methoxybenzene-1-sulfonyl chlorideHCID 50876025—

Reaction Steps

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-chloro-3-methoxy-phenylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455645B2
Source datasetuspto-grants-2013_06
ORD IDord-02435f84478d4cc187b6408aaba60737
Source noteuspto-grants-2013_06