N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide → 2,6-Difluoro-N-(4-methyl-5-(thiophen-3-yl)thiazol-2-yl)benzamide

HRID 1255126Notes

Reaction equation

HRID 1255126 reaction equation
Br[C:2]1[S:3][C:4](Br)=[CH:5][C:6]=1[C:7]1[S:11][C:10]([NH:12][C:13](=[O:22])[C:14]2[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=2[F:21])=[N:9][C:8]=1[CH3:23].O1C2C=CC(C3SC(NC(=O)C4C(F)=CC=CC=4F)=NC=3C)=CC=2OC1>>[F:21][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([F:20])[C:14]=1[C:13]([NH:12][C:10]1[S:11][C:7]([C:6]2[CH:5]=[CH:4][S:3][CH:2]=2)=[C:8]([CH3:23])[N:9]=1)=[O:22]

Participants

3

Reactant 2

HCID 24765406N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamideHCID 24765485N-(5-(2,5-Dibromothiophen-3-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide

Product 1

HCID 247654862,6-Difluoro-N-(4-methyl-5-(thiophen-3-yl)thiazol-2-yl)benzamide

Procedure

Compound 62 was prepared from was prepared from Compound 61 as described for the preparation of Compound 57.

Sources & evidence

ORD record
ord-448f23d8e2f34156a4da88827ded41df
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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