反应详情

Into a solution of Compound 68a (63.6 mg, 0.15 mmol) in EtOAc (2.0 mL) was added 5% Pd/C (50 mg). The mixture was stirred at room temperature under 1 atmosphere of hydrogen for 2 hours. The mixture was filtered through a short plug of silica, the filtrate was concentrated, the residue was purified by column chromatography on silica gel (eluted with 10-70% ethyl acetate in hexanes) to give Compound 69 (46 mg, 72%) as a white solid.

1. filtrationThe mixture was filtered through a short plug of silica
2. concentrationthe filtrate was concentrated
3. customthe residue was purified by column chromatography on silica gel (eluted with 10-70% ethyl acetate in hexanes)