HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(4-Cyano-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-difluoro-N-[4-[(Z)-hydroxyiminomethyl]-5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzamide | HCID 59004560 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Cyano-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide | HCID 24765580 | — |
Reaction Steps
Into a solution of Compound 72 (90 mg, 0.21 mmol) in 10 mL of CH2Cl2 was added 2-chloro-1-methylpyridium iodide (128 mg, 0.5 mmol) and NEt3 (0.1 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455658B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-1503df0986594359921199b734bc27b3 |
| Source note | uspto-grants-2013_06 |