Triethylamine → N-(4-Cyano-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide

HRID 1255136Notes

Reaction equation

HRID 1255136 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[C:10](/[CH:12]=[N:13]\O)[N:11]=1)=[O:5].CCN(CC)CC>C(Cl)Cl>[C:12]([C:10]1[N:11]=[C:7]([NH:6][C:4](=[O:5])[C:3]2[C:25]([F:29])=[CH:26][CH:27]=[CH:28][C:2]=2[F:1])[S:8][C:9]=1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:22])[F:23])[CH:16]=1)#[N:13]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 590045602,6-difluoro-N-[4-[(Z)-hydroxyiminomethyl]-5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzamide

Product 1

HCID 24765580N-(4-Cyano-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a solution of Compound 72 (90 mg, 0.21 mmol) in 10 mL of CH2Cl2 was added 2-chloro-1-methylpyridium iodide (128 mg, 0.5 mmol) and NEt3 (0.1 mL).

Sources & evidence

ORD record
ord-1503df0986594359921199b734bc27b3
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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