2,6-difluoro-N-(4-(prop-1-en-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide → 2,6-Difluoro-N-(5-(3-(trifluoromethyl)phenyl)-4-vinylthiazol-2-yl)benzamide

HRID 1255138Notes

Reaction equation

HRID 1255138 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[C:10]([CH:12](O)[CH3:13])[N:11]=1)=[O:5].FC1C=CC=C(F)C=1C(NC1SC(C2C=CC=C(C(F)(F)F)C=2)=C(C(C)=C)N=1)=O>>[F:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:16]=2)=[C:10]([CH:12]=[CH2:13])[N:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 247655792,6-difluoro-N-(4-(prop-1-en-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamideHCID 590045552,6-Difluoro-N-(4-(1-hydroxyethyl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide

Product 1

HCID 247655812,6-Difluoro-N-(5-(3-(trifluoromethyl)phenyl)-4-vinylthiazol-2-yl)benzamide

Procedure

Compound 75 was prepared from Compound 74 similarly as described for the preparation of Compound 68a.

Sources & evidence

ORD record
ord-a5d277754c194604a157111c2a4005c6
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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