Thiourea → N-(2'-amino-5-(3-(trifluoromethyl)phenyl)-4,4'-bithiazol-2-yl)-2,6-difluorobenzamide
Reaction equation
Br[CH2:2][C:3]([C:5]1[N:6]=[C:7]([NH:20][C:21](=[O:30])[C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])[S:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)=O.[NH2:31][C:32]([NH2:34])=[S:33].FC1C=CC=C(F)C=1C(NC1SC(C2C=CC=C(C(F)(F)F)C=2)=C(C2N=C(C)SC=2)N=1)=O>>[NH2:34][C:32]1[S:33][CH:2]=[C:3]([C:5]2[N:6]=[C:7]([NH:20][C:21](=[O:30])[C:22]3[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=3[F:29])[S:8][C:9]=2[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:31]=1Participants
4
Reactant 3
Product 1
Procedure
Compound 87 was prepared from Compound 85 and thiourea similarly as described for the preparation of Compound 86.
Sources & evidence
- ORD record
- ord-2e6e05d5081e4d9ba8ecbe652bc1122a
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08455658B2
Reaction notes
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