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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1255144Generated: November 2, 2026

Thiourea → N-(2'-amino-5-(3-(trifluoromethyl)phenyl)-4,4'-bithiazol-2-yl)-2,6-difluorobenzamide

https://huagongshe.com/reaction/1255144

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThioureaHCID 2723790—
ReactantN-(4-(2-Bromoacetyl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-2,6-difluorobenzamideHCID 24765772—
Reactant2,6-Difluoro-N-(2'-methyl-5-(3-(trifluoromethyl)phenyl)-4,4'-bithiazol-2-yl)benzamideHCID 59004499—
ProductN-(2'-amino-5-(3-(trifluoromethyl)phenyl)-4,4'-bithiazol-2-yl)-2,6-difluorobenzamideHCID 59004493—

Reaction Steps

Compound 87 was prepared from Compound 85 and thiourea similarly as described for the preparation of Compound 86.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455658B2
Source datasetuspto-grants-2013_06
ORD IDord-2e6e05d5081e4d9ba8ecbe652bc1122a
Source noteuspto-grants-2013_06