HRID1255145

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21613763

未命名化合物

反应SMILES：O=C(CBr)c1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1

HCID24765772

未命名化合物

反应SMILES：Cc1nc(-c2nc(NC(=O)c3c(F)cccc3F)sc2-c2cccc(C(F)(F)F)c2)cs1

HCID59004499

未命名化合物

PRODUCTS

产物

反应SMILES：CCOC(=O)c1nc(-c2nc(NC(=O)c3c(F)cccc3F)sc2-c2cccc(C(F)(F)F)c2)cs1

HCID59004509

未命名化合物

PROCEDURE

实验过程

Compound 88 was prepared from Compound 85 and ethyl thiooxamate similarly as described for the preparation of Compound 86.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-51c2a2fc33c94082afa26ffeffa7e828
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08455658B2
来源说明: uspto-grants-2013_06

反应SMILES

BrCC(C1N=C(NC(=O)C2C(F)=CC=CC=2F)SC=1C1C=CC=C(C(F)(F)F)C=1)=[O:4].[C:31]([O:36][CH2:37][CH3:38])(=S)[C:32]([NH2:34])=O.[F:39][C:40]1[CH:69]=[CH:68][CH:67]=[C:66]([F:70])[C:41]=1[C:42]([NH:44][C:45]1[S:46][C:47]([C:56]2[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=2)=[C:48]([C:50]2N=C(C)[S:53][CH:54]=2)[N:49]=1)=[O:43]>>[F:39][C:40]1[CH:69]=[CH:68][CH:67]=[C:66]([F:70])[C:41]=1[C:42]([NH:44][C:45]1[S:46][C:47]([C:56]2[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=2)=[C:48]([C:50]2[N:34]=[C:32]([C:31]([O:36][CH2:37][CH3:38])=[O:4])[S:53][CH:54]=2)[N:49]=1)=[O:43]