2-ethoxy-2-thioxoAcetamide → Ethyl 2'-(2,6-difluorobenzamido)-5'-(3-(trifluoromethyl)phenyl)-4,4'-bithiazole-2-carboxylate
Reaction equation
BrCC(C1N=C(NC(=O)C2C(F)=CC=CC=2F)SC=1C1C=CC=C(C(F)(F)F)C=1)=[O:4].[C:31]([O:36][CH2:37][CH3:38])(=S)[C:32]([NH2:34])=O.[F:39][C:40]1[CH:69]=[CH:68][CH:67]=[C:66]([F:70])[C:41]=1[C:42]([NH:44][C:45]1[S:46][C:47]([C:56]2[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=2)=[C:48]([C:50]2N=C(C)[S:53][CH:54]=2)[N:49]=1)=[O:43]>>[F:39][C:40]1[CH:69]=[CH:68][CH:67]=[C:66]([F:70])[C:41]=1[C:42]([NH:44][C:45]1[S:46][C:47]([C:56]2[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=2)=[C:48]([C:50]2[N:34]=[C:32]([C:31]([O:36][CH2:37][CH3:38])=[O:4])[S:53][CH:54]=2)[N:49]=1)=[O:43]Participants
4
Reactant 3
Product 1
Procedure
Compound 88 was prepared from Compound 85 and ethyl thiooxamate similarly as described for the preparation of Compound 86.
Sources & evidence
- ORD record
- ord-51c2a2fc33c94082afa26ffeffa7e828
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08455658B2
Reaction notes
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