HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate | HCID 24765115 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate hydrochloride | HCID 86761875 | — |
Reaction Steps
A solution of Compound 36 (21 mg, 0.05 mmol) in 1 mL of Et2O was treated with 0.1 mL of 2M HCl in Et2O. The precipitate formed was collected, washed with Et2O and dried to give Compound 111 (20 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455658B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9226984950d34837a9e0e50af4702741 |
| Source note | uspto-grants-2013_06 |