Hydrochloric Acid → Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate hydrochloride

HRID 1255153Notes

Reaction equation

HRID 1255153 reaction equation
[CH3:1][C:2]1[CH:29]=[N:28][CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[C:10]([C:12]([O:14][CH3:15])=[O:13])[N:11]=1)=[O:5].[ClH:30]>CCOCC>[ClH:30].[CH3:1][C:2]1[CH:29]=[N:28][CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:25])[F:23])[CH:17]=2)=[C:10]([C:12]([O:14][CH3:15])=[O:13])[N:11]=1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24765115Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate

Product 1

HCID 86761875Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of Compound 36 (21 mg, 0.05 mmol) in 1 mL of Et2O was treated with 0.1 mL of 2M HCl in Et2O. The precipitate formed was collected, washed with Et2O and dried to give Compound 111 (20 mg) as a white solid.

Workup

  1. customThe precipitate formed
  2. customwas collected
  3. washwashed with Et2O
  4. customdried

Sources & evidence

ORD record
ord-9226984950d34837a9e0e50af4702741
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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