2-(2,6-Difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid → 2-(3-Methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid

HRID 1255154Notes

Reaction equation

HRID 1255154 reaction equation
Cl.[CH3:2][C:3]1[CH:30]=[N:29][CH:28]=[CH:27][C:4]=1[C:5]([NH:7][C:8]1[S:9][C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:11]([C:13]([O:15]C)=[O:14])[N:12]=1)=[O:6].FC1C=CC=C(F)C=1C(NC1SC(C2C=CC=C(C(F)(F)F)C=2)=C(C(O)=O)N=1)=O>>[CH3:2][C:3]1[CH:30]=[N:29][CH:28]=[CH:27][C:4]=1[C:5]([NH:7][C:8]1[S:9][C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1)=[O:6]

Participants

3

Reactant 2

HCID 590044862-(2,6-Difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acidHCID 86761875Methyl 2-(3-methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate hydrochloride

Product 1

HCID 590045102-(3-Methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid

Procedure

Compound 112 was prepared from Compound 111 by hydrolysis similarly as described for the preparation of Compound 66.

Sources & evidence

ORD record
ord-834d54e4c8724dc18723c03aa88c1860
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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