反应详情

A mixture of the title compound from Example 19 Step B (2.0 g, 2.2 mmol), 23 mL 1,4-dioxane and concentrated HCl (2 mL) was stirred for 14 h. Concentrated HCl (8 mL) was added dropwise. After 1 h, concentrated HCl (4 mL) was added dropwise. After 4 h, the reaction mixture was diluted with water and concentrated to a solid form. The solid was further washed by ether twice to give the crude title compound which was used without further purification: LCMS m/z 275.5 [M+H]+.

1. waitAfter 1 h
2. waitAfter 4 h
3. concentrationconcentrated to a solid form
4. washThe solid was further washed by ether twice