Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate → Ethyl 1-[6-(2-methoxy-5-methylphenyl)-4-nitropyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole 4-carboxylate

HRID 1255203Notes

Reaction equation

HRID 1255203 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([C:12]2[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=2[O:19][CH3:20])[N:4]=1)[NH2:2].C(O[CH:24]=[C:25]([C:31](=O)[C:32]([F:35])([F:34])[F:33])[C:26]([O:28][CH2:29][CH3:30])=[O:27])C>>[CH3:20][O:19][C:13]1[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=1[C:5]1[N:4]=[C:3]([N:1]2[C:31]([C:32]([F:33])([F:34])[F:35])=[C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:24]=[N:2]2)[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=1

Participants

3

Reactant 2

HCID 4685753Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoateHCID 671593122-Hydrazino-6-(2-methoxy-5-methylphenyl)-4-nitropyridine

Product 1

HCID 67159086Ethyl 1-[6-(2-methoxy-5-methylphenyl)-4-nitropyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole 4-carboxylate

Procedure

Reaction of the title compound from Example 19 Step C with ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate, according to chemistry described in Example 1 Step A, provided the title compound: LCMS m/z 451.6 [M+H]+.

Sources & evidence

ORD record
ord-23e51d315fa7460d862f3fd6be67ef43
Source dataset
uspto-grants-2013_06
Patent number
US08455638B2

Reaction notes

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