Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate → Ethyl 1-[6-(2-methoxy-5-methylphenyl)-4-nitropyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole 4-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate	HCID 4685753	—
Reactant	2-Hydrazino-6-(2-methoxy-5-methylphenyl)-4-nitropyridine	HCID 67159312	—
Product	Ethyl 1-[6-(2-methoxy-5-methylphenyl)-4-nitropyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole 4-carboxylate	HCID 67159086	—

Reaction Steps

Reaction of the title compound from Example 19 Step C with ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate, according to chemistry described in Example 1 Step A, provided the title compound: LCMS m/z 451.6 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08455638B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-23e51d315fa7460d862f3fd6be67ef43
Source note	uspto-grants-2013_06