[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol → 5'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

HRID 1255213Notes

Reaction equation

HRID 1255213 reaction equation
F[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[C:18]([C:19]([F:22])([F:21])[F:20])=[C:17]([C:23]([O:25]CC)=[O:24])[CH:16]=[N:15]3)[N:9]=2)=[CH:6][C:5]([CH3:28])=[CH:4][N:3]=1.[CH3:29][C:30]1[CH:31]=[C:32]([C:38]2[CH:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][CH:39]=2)[CH:33]=[CH:34][C:35]=1[CH2:36][OH:37]>>[CH3:28][C:5]1[CH:6]=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[C:18]([C:19]([F:21])([F:22])[F:20])=[C:17]([C:23]([OH:25])=[O:24])[CH:16]=[N:15]3)[N:9]=2)[C:2]([O:37][CH2:36][C:35]2[CH:34]=[CH:33][C:32]([C:38]3[CH:43]=[CH:42][C:41]([C:44]([F:45])([F:46])[F:47])=[CH:40][CH:39]=3)=[CH:31][C:30]=2[CH3:29])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 22280004[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanolHCID 67159625Ethyl 1-(2'-fluoro-5'-methyl-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 578259655'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Procedure

The title compound was prepared according to the procedure described in Example 237 Step B, by reaction of the title compound from Example 238 Step B with [3-methyl-4′-(trifluoromethyl)biphenyl-4-yl]methanol (PCT Publication WO2005118542): LCMS m/z 612.9 [M+H]+; 1H NMR (500 MHz, acetone-d6) δ 8.18 (m, 2H), 7.91 (d, J=8.2 Hz, 2H), 7.80 (m, 3H), 7.63 (m, 2H), 5.66 (s, 2H), 2.51 (s, 3H), 2.37 (s, 3H).

Sources & evidence

ORD record
ord-50d365f1ad674128b5ab3690e4210436
Source dataset
uspto-grants-2013_06
Patent number
US08455638B2

Reaction notes

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