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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1255213Generated: November 1, 2026

[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol → 5'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

https://huagongshe.com/reaction/1255213

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanolHCID 22280004—
ReactantEthyl 1-(2'-fluoro-5'-methyl-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateHCID 67159625—
Product5'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acidHCID 57825965—

Reaction Steps

The title compound was prepared according to the procedure described in Example 237 Step B, by reaction of the title compound from Example 238 Step B with [3-methyl-4′-(trifluoromethyl)biphenyl-4-yl]methanol (PCT Publication WO2005118542): LCMS m/z 612.9 [M+H]+; 1H NMR (500 MHz, acetone-d6) δ 8.18 (m, 2H), 7.91 (d, J=8.2 Hz, 2H), 7.80 (m, 3H), 7.63 (m, 2H), 5.66 (s, 2H), 2.51 (s, 3H), 2.37 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455638B2
Source datasetuspto-grants-2013_06
ORD IDord-50d365f1ad674128b5ab3690e4210436
Source noteuspto-grants-2013_06