HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol → 5'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol | HCID 22280004 | — |
| Reactant | Ethyl 1-(2'-fluoro-5'-methyl-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | HCID 67159625 | — |
| Product | 5'-Methyl-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid | HCID 57825965 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 237 Step B, by reaction of the title compound from Example 238 Step B with [3-methyl-4′-(trifluoromethyl)biphenyl-4-yl]methanol (PCT Publication WO2005118542): LCMS m/z 612.9 [M+H]+; 1H NMR (500 MHz, acetone-d6) δ 8.18 (m, 2H), 7.91 (d, J=8.2 Hz, 2H), 7.80 (m, 3H), 7.63 (m, 2H), 5.66 (s, 2H), 2.51 (s, 3H), 2.37 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455638B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-50d365f1ad674128b5ab3690e4210436 |
| Source note | uspto-grants-2013_06 |