[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol → 1-(5'-Chloro-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

HRID 1255214Notes

Reaction equation

HRID 1255214 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N:15]3[C:19]([C:20]([F:23])([F:22])[F:21])=[C:18]([C:24]([O:26]CC)=[O:25])[CH:17]=[N:16]3)[N:10]=2)[C:5](F)=[N:6][CH:7]=1.[CH3:29][C:30]1[CH:31]=[C:32]([C:38]2[CH:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][CH:39]=2)[CH:33]=[CH:34][C:35]=1[CH2:36][OH:37]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N:15]3[C:19]([C:20]([F:23])([F:22])[F:21])=[C:18]([C:24]([OH:26])=[O:25])[CH:17]=[N:16]3)[N:10]=2)[C:5]([O:37][CH2:36][C:35]2[CH:34]=[CH:33][C:32]([C:38]3[CH:43]=[CH:42][C:41]([C:44]([F:45])([F:46])[F:47])=[CH:40][CH:39]=3)=[CH:31][C:30]=2[CH3:29])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 22280004[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanolHCID 67159236Ethyl 1-(5'-chloro-2'-fluoro-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 252317001-(5'-Chloro-2'-{[3-methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-2,3'-bipyridin-6-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Procedure

The title compound was prepared according to the procedure described in Example 237 Step B, by reaction of the title compound from Example 239 Step A with [3-methyl-4′-(trifluoromethyl)biphenyl-4-yl]methanol (PCT Publication WO2005118542): LCMS m/z 632.7 [M+H]+; 1H NMR (500 MHz, acetone-d6) δ 8.22 (m, 2H), 7.92 (d, J=8.2 Hz, 2H), 7.83 (m, 3H), 7.63 (m, 2H), 5.70 (s, 2H), 2.52 (s, 3H).

Sources & evidence

ORD record
ord-4a60f7d854654ea194d096a2aea52d0d
Source dataset
uspto-grants-2013_06
Patent number
US08455638B2

Reaction notes

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