反应详情

Borane dimethyl sulfide complex (2M in THF, 8.6 mL) was added dropwise to a solution of 2-(3-(bromomethyl)-5-methylphenyl)acetic acid [Aromatic Intermediate 23, step a] (2.1 g) in THF (50 mL) at 0° C. and the mixture stirred for 10 minutes at this temperature and then at room temperature for 1 hour. The reaction mixture was quenched by dropwise addition of methanol, the solvents were evaporated under reduced pressure and the residue was purified by flash silica chromatography using 30% ethyl acetate in isohexane as solvent. Fractions containing the product were evaporated to dryness to afford the titled compound. Yield 1.40 g.

1. waitat room temperature for 1 hour
2. customThe reaction mixture was quenched by dropwise addition of methanol
3. customthe solvents were evaporated under reduced pressure
4. customthe residue was purified by flash silica chromatography
5. additionFractions containing the product
6. customwere evaporated to dryness