(Diethylamino)sulfur trifluoride → HCID 66602279, compound

HRID 1255393Notes

Reaction equation

HRID 1255393 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][C:11]=1[CH2:12]O)[N:8]=[C:7]([C:14]([F:17])([F:16])[F:15])[C:6]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:5]2.C(N(S(F)(F)[F:29])CC)C>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[N:10][C:11]=1[CH2:12][F:29])[N:8]=[C:7]([C:14]([F:17])([F:16])[F:15])[C:6]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:5]2

Participants

3

Reactant 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 66602255HCID 66602255, compound

Product 1

HCID 66602279HCID 66602279, compound

Procedure

In a similar procedure to Example 12, Stage 3, ethyl 6-fluoro-7-hydroxymethyl-2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylate was reacted with N,N-diethylaminosulfur trifluoride to give the required product. as a pale brown solid, 1H NMR (CDCl3) δ: 8.74 (1H, s), 8.03 (1H, d), 5.83 (2H, double doublet), 4.51 (1H, q), 1.45 (3H, t).

Sources & evidence

ORD record
ord-efb9c099e59c41f987292835e8a5e4a7
Source dataset
uspto-grants-2013_06
Patent number
US08461083B2

Reaction notes

Loading…