Hydrochloric Acid → HCID 67446199, compound

Participants

Reaction Steps

Hydrochloric acid (4M in dioxane, 60 mL) was added to a solution of (R)-tert-butyl 3,3-difluorocyclopentylcarbamate (4.61 g, 20.8 mmol) in dioxane (40 mL) at 0° C. After complete addition, the reaction mixture was allowed to warm to room temperature and stirred for 2 hours. The solvent was removed in vacuo and the residue was triturated with diethylether to afford the title compound as an off-white solid (2.68 g, 82% yield).

Provenance & Evidence